Registration Dossier
Registration Dossier
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EC number: 294-268-8 | CAS number: 91697-07-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
read across to the stuctural very similar substance Sulfosuccinic (FA C12-18)E, 2Na.
The 96‑hour LC50of Sulfosuccinic (FA C12-18)E, 2Na was deviated to be 2.0 mg/L.
The results of this study are considered relevant and reliable for the risk assessment.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2 mg/L
Additional information
No fish study (OECD 203) is available for the registered substance. The data gap, however, is brigded by read across to the stuctural very similar substance Sulfosuccinic (FA C12-18)E, 2Na.
In the Klimisch 1 GLP study from Kimmel (2013) (read across study) the acute toxicity of Sulfosuccinic (FA C12-18)E, 2Na to zebra fish (Danio rerio) was determined in a 96‑hour semi-static test with daily test medium renewal according to the EU Commission Directive 92/69/, Part C.1, the Commission Regulation (EC) No 440/2008, Part C.1 and the OECD Guideline for Testing of Chemicals No. 203 (1992). The following nominal concentrations were tested: 0.15, 0.47, 1.5, 4.7 and 15 mg/L mg test item/L. Additionally, a control (test water without test item) was tested in parallel.
The measured concentrations of the test item in the test media of the test concentrations of 0.15 to 15 mg/L were between 81 and 112% of the nominal values at the start of the test and below Limit of Quantification (LOQ) to 109% at the end of each renewal period. Thus, the correct dosage of the test item was confirmed, but the test item concentrations of the two lowest concentrations declined below 80% over the renewal period of 24 hours. Therefore the biological results were related to the following mean measured test item concentrations: control, 0.090, 0.33, 1.6, 4.8 and 16 mg test item/L.
In the control and at the test concentrations up to and including 0.090 mg/L, all fish survived until the end of the test and no visible abnormalities were observed in the test fish. At the next higher test concentration of 0.33 mg/L, three test fish showed one or several visible abnormalities. One of the seven test fish died at this test concentration. At the test concentration of 4.8 mg/L all test fish were dead after 48 hours of test duration while at the highest test concentration of 16 mg/L, all fish were dead already after 24 hours of test duration. Thus, the 96‑hour NOEC and LC0of Sulfosuccinic (FA C12-18)E, 2Na to zebra fish were both determined to be 0.090 mg/L. The 96‑hour LC50of Sulfosuccinic (FA C12-18)E, 2Na was calculated to be 2.0 mg/L with a 95% confidence interval of 0.8-3.3 mg/L. The 96‑hour LC100was 4.8 mg/L.
The results of this study are considered relevant and reliable for the risk assessment.
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