Registration Dossier
Registration Dossier
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EC number: 294-268-8 | CAS number: 91697-07-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
read across to the stuctural very similar substance Sulfosuccinic (FA C12-18)E, 2Na.
OECD 201: The 72 -hour ErC10 and ErC50 are 10 and 60 mg test item/L based on nominal concentrations.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 60 mg/L
- EC10 or NOEC for freshwater algae:
- 10 mg/L
Additional information
No algae study (OECD 201) is available for the registered substance. The data gap, however, is brigded by read across to the stuctural very similar substance Sulfosuccinic (FA C12-18)E, 2Na.
In the Klimisch 1 GLP study from Kimmel (2013) 8read across study) the toxicity of Sulfosuccinic (FA C12-18)E, 2Na to Desmodesmus subspicatus was determined in a static 72-Hour Algal Growth Inhibition Test. The test was performed according to OECD 201 and EU Method C.3. The nominal concentrations of the test item of6.25, 12.5, 25, 50 and 100 mg test item/L were tested in parallel with a control. Dose verification analysis was performed . The measured concentrations of the test item were between 92 and 108 of the nominal values at the start of the test and between 98 and 1ß4% at the end of the test. therefore, the biological results were based on nominal concentrations. In order to determine the growth of the cultures, the cultures were measured with the fluorescent method . The cell density was determined at 0, 24, 48 and 72 hours. The growth of the control cultures fulfilled the validity criteria from OECD 201 (2006). The 72 -hour ErC10 and ErC50 are 10 and 60 mg test item/L based on nominal concentrations.
This information is considered to be relevant and reliable for the further risk assessment.
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