Registration Dossier
Registration Dossier
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EC number: 207-256-4 | CAS number: 456-04-2
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: case report
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, acceptable for assessment. Report on a case of human allergic contact dermatitis induced by the test substance.
Data source
Reference
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis from 3-(α-methoxy)methylenebenzofuran-2(3H)-one (MBF) and α-chloro-4-fluoroacetophenone (CFAP) in chemical process workers.
- Author:
- Boffa MJ, Heron RJL, Wilkinson SM, Beck MH
- Year:
- 1 996
- Bibliographic source:
- Contact Dermatitis 34: 434-435
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- Case report on occupational sensitization to the test substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- α-chloro-4-fluoroacetophenone
- EC Number:
- 207-256-4
- EC Name:
- α-chloro-4-fluoroacetophenone
- Cas Number:
- 456-04-2
- Molecular formula:
- C8H6ClFO
- IUPAC Name:
- 2-chloro-1-(4-fluorophenyl)ethan-1-one
- Details on test material:
- - Name of test material (as cited in study report): α-chloro-4-fluoroacetophenone (CFAP)
- Substance type: organic chemical intermediate
- Physical state: not reported
- Analytical purity: not reported
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 1
- Sex: male
- Age: 44
- Race: no data - Clinical history:
- - History of allergy or casuistics for study subject or populations: no data
- Symptoms, onset and progress of the disease: 18-month history of recurrent facial eczema.
- Exposure history: regular occupational handling of the test substance
- Aggravating factors both in home and workplace: no data
- Family history: not applicable - Controls:
- not applicable
- Route of administration:
- other: dermal and inhalation possible
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: occlusive
- Description of patch: not reported
- Vehicle / solvent: toluene
- Concentrations: 0.005%
- Volume applied: not reported
- Testing/scoring schedule: readings after 2 and 4 days
- Removal of test substance: no data
EXAMINATIONS
- Grading/Scoring system: not reported
Results and discussion
- Results of examinations:
- SYMPTOMS
- Frequency, level, duration of symptoms observed: skin problems of patient developed only at work
RESULT OF CASE REPORT: Patient appeared to have been sensitized following occupational exposure
Applicant's summary and conclusion
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