Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-256-4 | CAS number: 456-04-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study, well documented with accepted restrictions (no GLP).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
- Principles of method if other than guideline:
- BASF-Test
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- α-chloro-4-fluoroacetophenone
- EC Number:
- 207-256-4
- EC Name:
- α-chloro-4-fluoroacetophenone
- Cas Number:
- 456-04-2
- Molecular formula:
- C8H6ClFO
- IUPAC Name:
- 2-chloro-1-(4-fluorophenyl)ethan-1-one
- Details on test material:
- - Name of test material (as cited in study report): omega-chlor-para-fluoracetophenon [German]
- Physical state: aqueous solution
- Analytical purity: 98 %, technical grade
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach, FRG
- Age at study initiation: no data
- Weight at study initiation: mean weights: males 189.25 g, females 181.25 g (animals of comparable weight: ± 20 % of the mean weight)
- Fasting period before study: 16 hours before administration
- Housing: 5/cage
- Diet: Kliba Labordiaet 343, ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 1 wk
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 4.64, 2.15, 1.00, 0.464 % (w/v)
- Amount of vehicle (if gavage): 10 ml
- Justification for choice of vehicle: aqueous formulation corresponds to the physiological medium
MAXIMUM DOSE VOLUME APPLIED: 464.0 mg/kg bw - Doses:
- 464.0, 215.0, 100.0, 46.4 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: recording of signs and symptoms severeal times on the day of administration, at least once each workday; check for moribund and dead animals twice each workday and once on holidays; weighing on day 7 and day 13
- Necropsy of survivors performed: yes, gross-pathological examination
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 248 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 215 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 215 - < 464 mg/kg bw
- Mortality:
- 464 mg/kg bw:
Males and females: 5/5 each after 1 d
215 mg/kg bw:
Males: 0/5
Females: 3/5 after 1 d
100 mg/kg bw:
Males: 0/5
Females: 1/5 after 14 d (probably not due to test substance, therefore not considered for LD50 determination)
46.4 mg/kg bw:
Males and females: 0/5 each - Clinical signs:
- other: 464 mg/kg: Males and females: dyspnea, apathy, staggering, piloerection, diarrhea, poor general state 215 mg/kg bw: males and females: dyspnea, apathy, piloerection, impaired general state, poor general state 100 mg/kg bw: Males: piloerection Fema
- Gross pathology:
- Deceased animals (male and female):
General congestion; glandular stomach: reddened mucosa
One female of the 100 mg/kg bw group: perforation of stomach with fibrinous peritonitis
Sacrificed animals (male and female):
46.4 mg/kg bw: no pathological findings noted.
100 mg/kg bw: forestomach: thickening of the wall.
215 mg/kg bw: forestomach: thickening of the wall, intraabdominal adhesions.
Any other information on results incl. tables
Mean body weights (g):
Males:
Dose (mg/kg bw) | ||||
Time | 464.0 | 215.0 | 100.0 | 46.4 |
Beginning | 196 | 190 | 189 | 182 |
7 d | - | 237 | 251 | 259 |
13 d | - | 273 | 282 | 291 |
Females:
Dose (mg/kg bw) | ||||
Time | 464.0 | 215.0 | 100.0 | 46.4 |
Beginning | 180 | 180 | 178 | 187 |
7 d | - | 211 | 208 | 226 |
13 d | - | 222 | 222 | 239 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.