Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Principles of method if other than guideline:
Acute toxicity of 2,6-dimethylcyclohexylamine in rats after i.p. injection
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6-dimethylcyclohexylamine
EC Number:
229-942-2
EC Name:
2,6-dimethylcyclohexylamine
Cas Number:
6850-63-1
Molecular formula:
C8H17N
IUPAC Name:
2,6-dimethylcyclohexan-1-amine
Details on test material:
no data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 0.5% carboxymethylcellulose in water
Doses:
46, 100, 147, or 215 mg/kg bw (concentrations: 0.46, 1.0, 1.5, 2.1%)
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
108 mg/kg bw
95% CL:
77 - 142
Sex:
male
Dose descriptor:
LD50
Effect level:
90 mg/kg bw
95% CL:
38 - 139
Sex:
female
Dose descriptor:
LD50
Effect level:
130 mg/kg bw
95% CL:
70 - 202

Any other information on results incl. tables

Clinical signs comparable to those described after oral application.

Applicant's summary and conclusion

Conclusions:
The LD50 after i.p. injection was 108 mg/kg bw in male and female rats.
Executive summary:

The acute toxicity of 2,6 -dimethylcyclohexylamine in Wistar rats after i.p. injection was tested (4 dose levels, n=5 per sex per dose; 14 d post exposure period). The LD50 was 108 mg/kg bw in males and females combined, 90 mg/kg bw in males and 130 mg/kg bw in females.