Registration Dossier
Registration Dossier
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EC number: 805-733-7 | CAS number: 256504-39-9
Boiling point
Administrative data
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-07-13 to2019-10-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 103 (Boiling point/boiling range)
- Version / remarks:
- adopted July 27, 1995
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Version / remarks:
- 31 May 2008
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 830.7220 (Boiling Point / Boiling Range)
- Version / remarks:
- August 1996
- GLP compliance:
- no
- Type of method:
- method according to Siwoloboff
Test material
- Reference substance name:
- ethyl 5-amino-1-[(2-fluorophenyl)methyl]-1H-pyrazole-3-carboxylate
- EC Number:
- 805-733-7
- Cas Number:
- 256504-39-9
- Molecular formula:
- C13H14FN3 O2
- IUPAC Name:
- ethyl 5-amino-1-[(2-fluorophenyl)methyl]-1H-pyrazole-3-carboxylate
- Test material form:
- solid
Constituent 1
Results and discussion
Boiling point
- Key result
- Boiling pt.:
- 243.7 °C
- Atm. press.:
- 101.325 kPa
Any other information on results incl. tables
The determination of the boiling point was performed by visual judgement using the capillary.
At about 360 °C in the preliminary tests, the number of air bubbles increased. To confirm the result obtained in the preliminary tests, the determination of the boiling point was performed three times, heating quickly up to 340 °C and afterwards slowly using a heating rate of 0.5 °C/min.
A clear normal boiling point, as defined in the guideline with a current stream of bubbles evolving from the capillary, was observed at a heating temperature of 243.7 °C.
Applicant's summary and conclusion
- Conclusions:
- In conclusion, using the capillary method according to EU A.2, OECD 103, OPPTS 830.722 the test item Aminopyrazol started boiling at 243.7 °C (516.9 K) at normal pressure (101.325 kPa).
- Executive summary:
Title: Aminopyrazol: Determination of the Boiling Point
Purpose: The purpose of this study was to evaluate the boiling point of
Aminopyrazol by the capillary method using an electronic controlled heating system.
Guidelines/Recommendations:
This study was based on the procedures indicated by the following internationally accepted methods:
-Commission Regulation (EC) No.440/2008 laying down test methods pursuant to Regulation (EC) No.1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) (originally published as Council Regulation (EC) No.440/2008, corrigendum according to Official Journal of the European Union (EN) dated June 3, 2008, L 143/55), Annex, Part A, A.2.: “Boiling Temperature”, Official Journal of the European Union, L 142, Volume 51, 31 May 2008
-Organization for Economic Co-operation and Development (OECD), Guidelines for Testing of Chemicals, Guideline No.103, “Boiling Point”, adopted July 27, 1995
-Product Properties Test Guideline OPPTS 830.7220 of the United States Environment Protection Agency (EPA), August 1996
Results:
The determination of the boiling point was performed by visual judgement using the capillary.
At about 360 °C in the preliminary tests, the number of air bubbles increased. To confirm the result obtained in the preliminary tests, the determination of the boiling point was performed three times, heating quickly up to 340 °C and afterwards slowly using a heating rate of 0.5 °C/min.
A clear normal boiling point, as defined in the guideline with a current stream of bubbles evolving from the capillary, was observed at a heating temperature of 243.7 °C.
Conclusion:
In conclusion, using the capillary method according to EU A.2, OECD 103, OPPTS 830.722 the test item Aminopyrazol started boiling at 243.7 °C (516.9 K) at normal pressure (101.325 kPa). This study is classified acceptable and satisfies the guideline requirements for boiling point studies.
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