1H-Pyrazole-3-carboxylic acid, 5-amino-1-[(2-fluorophenyl)methyl]-, ethyl ester

Guidance on Safe Use

First-aid measures

General advice: Take off contaminated clothing and shoes immediately. Call a physician immediately.

Ii inhaled: Remove to fresh air. If symptoms persist, call a physician.

Skin contact: In case of skin contact with powders or solution immediately rinse the areas affected continuously with water and then wash with soap

and water. Do NOT use solvents or thinners.

Eye contact: Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.

If swallowed: If swallowed, seek medical advice immediately and show  this container or label.

Fire-fighting measures

Suitable extinguishing media: Any

Specific hazards during fire fighting: Fire may cause evolution of: Nitrogen oxides (NOx), Carbon oxides, Hydrogen fluoride

Special protective equipment for fire-fighters: In the event of fire, wear self-contained breathing apparatus.

Further information: Prevent fire extinguishing water from contaminating surface water or the ground water system.

Accidental release measures

Personal Precautions: Use personal protective equipment.

Enviromental Precautions:  Do not flush into surface water or sanitary sewer system.

Methods for cleaning or taking up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

Further accidental release measures: Avoid dust formation.

Handling and storage

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.

 

Written confirmation of application of Strictly Controlled Conditions has been received from every affected Distributor and Downstream Processor/User of the Registrant’s intermediate.

Handling

Hygiene measures: Wash hands and face with alkaline soap before breaks and after handling the product. Use protective skin cream before handling

the product. Take off contaminated clothing and shoes immediately. Smoking, eating and drinking should be prohibited in the application area.

Advice on safe handling: Avoid contact with skin, eyes and clothing. Measures must be taken to prevent dust explosion when processing in fine

crystalline form. Avoid dust formation.

Storage

Requirements for storage areas and containers: Keep container tightly closed in a dry and well-ventilated place. Protect from light. Keep away from

heat.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

2811

Shipping information

Proper shipping name and description:

TOXIC SOLID, ORGANIC, N.O.S.
(PYRAZOL DERIVATIVE)

Chemical name:

PYRAZOL DERIVATIVE

Language:

English

Labels:

6.1

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

2811

Shipping

Labels:

6.1

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

2811

Shipping information

Proper shipping name and description:

TOXIC SOLID, ORGANIC, N.O.S.
(PYRAZOL DERIVATIVE)

Chemical name:

PYRAZOL DERIVATIVE

Labels:

6.1

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

2811

Shipping information

Proper shipping name and description:

TOXIC SOLID, ORGANIC, N.O.S.
(PYRAZOL DERIVATIVE)

Chemical name:

PYRAZOL DERIVATIVE

Labels:

6.1

Remarks

SpecialProvisions

Exposure controls / personal protection

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.

 

Written confirmation of application of Strictly Controlled Conditions has been received from every affected Distributor and Downstream Processor/User of the Registrant’s intermediate.

Personal protective equipment

Respiratory protection: respirator with P3 filter

Eye protection: safety glasses with side-shields

Hand protection: During the handling of the substance according to the intended use protection gloves from nitrile rubber have been proved. During the handling of pure solid substances or powder mixtures a permeation of the rubber material is not to be expected. In case of doubt, especially

during handling of the substance together with organic solvents, the stability of the protection gloves has to be clarified with the manufacturer.

Skin and body protection: Choose body protection according to the amount and concentration of the dangerous substance at the work place.

Stability and reactivity

Conditions to avoid: no data available

Materials to avoid: no data available

Hazardous reactions: None known.

Disposal considerations

During the whole life cycle of the substance all necessary measures in accordance to art. 18(4) of (EC) 1907/2006 are undertaken. The substance is handled under strictly controlled conditions.

Dispose in accordance with current regulations and, if necessary, after consultation with the site operator and/or with the responsible authority, the product may be taken to a waste disposal site or incineration plant.