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EC number: 805-733-7 | CAS number: 256504-39-9
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-07-11 to 2019-10-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD and EU guideline study, GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- March 23, 2006
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- August 24, 2009
- GLP compliance:
- no
- Type of method:
- effusion method: isothermal thermogravimetry
Test material
- Reference substance name:
- ethyl 5-amino-1-[(2-fluorophenyl)methyl]-1H-pyrazole-3-carboxylate
- EC Number:
- 805-733-7
- Cas Number:
- 256504-39-9
- Molecular formula:
- C13H14FN3 O2
- IUPAC Name:
- ethyl 5-amino-1-[(2-fluorophenyl)methyl]-1H-pyrazole-3-carboxylate
- Test material form:
- solid
Constituent 1
Results and discussion
Vapour pressure
- Key result
- Test no.:
- #1
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: This value however is expected to be overestimated, because it was determined from the molten material.
Any other information on results incl. tables
The isothermal thermogravimetric effusion method was applied for the determination of the vapour pressure of Aminopyrazol.
A value of the vapour pressure of the test item was determined using the data obtained between 140 °C and 170 °C. The vapour pressure of the test item was calculated (mean of three determinations) to: 5.94 x 10-5 Pa at 20 °C.
This value however is expected to be overestimated, because it was determined from the molten material.
Applicant's summary and conclusion
- Conclusions:
- The isothermal thermogravimetric effusion method was chosen for the determination of the vapour pressure of Aminopyrazol. A value of the vapour pressure of the test item was determined using the data obtained between 140 °C and 170 °C. The vapour pressure of the test item was calculated (mean of three determinations) to: 0.0000594 Pa at 20 °C.
- Executive summary:
Title:
Aminopyrazol: Determination of the Vapour Pressure by Isothermal Thermogravimetry
Purpose:
The purpose of the study was to determine the vapour pressure of the test item using the isothermal thermogravimetric effusion method. The evaporation rates of the test item at elevated temperatures and ambient pressure were determined by monitoring the weight loss over the time.
Guidelines/Recommendations:
This study was based on the procedures indicated by the following internationally accepted methods:
-European Community (EC), EC No. 761/2009, Part A: Methods for the Determination of Physico-Chemical Properties, Guideline A.4: “Vapour Pressure”, Official Journal of the European Union No. L220, August 24, 2009
-Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for the Testing of Chemicals No. 104: “Vapour Pressure”, March 23, 2006
Results / Conclusion:
The isothermal thermogravimetric effusion method was applied for the determination of the vapour pressure of Aminopyrazol.
A value of the vapour pressure of the test item was determined using the data obtained between 140 °C and 170 °C. The vapour pressure of the test item was calculated (mean of three determinations) to: 5.94 x 10-5 Pa at 20 °C.
This study is classified acceptable and satisfies the guideline requirements for vapour pressure studies.
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