Registration Dossier
Registration Dossier
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EC number: 292-588-2 | CAS number: 90640-67-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study did not follow any guideline and was not performed according to GLP. Route is i.p. Limited reporting.
Data source
Reference
- Reference Type:
- publication
- Title:
- Antidotes for zinc intoxication in mice
- Author:
- Llobet, J.M., Domingo. J.L., Corbella, J.
- Year:
- 1 988
- Bibliographic source:
- Arch Toxicol. 61 : 321 -323
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Sixteen chelating agents were examined to determine their relative efficacy as antidotes in acute zinc acetate intoxication in mice after i.p. administration.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Amines, polyethylenepoly-, triethylenetetramine fraction
- EC Number:
- 292-588-2
- EC Name:
- Amines, polyethylenepoly-, triethylenetetramine fraction
- Cas Number:
- 90640-67-8
- Molecular formula:
- C6H18N4, C8H20N4
- IUPAC Name:
- Amines, polyethylenepoly-, triethylenetetramine fraction
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Named in the report: triethylenetetramine (TTHA)
substance was obtained from Sigma Chemical Company (St. Louis, Mo., USA)
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 0.9% saline
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 3.2 other: mmol/kg
- Based on:
- test mat.
- Remarks on result:
- other: i.p.
Applicant's summary and conclusion
- Conclusions:
- The LD50 of the test substance via the intraperitoneal route was indicated to be 3.2 mmol/kg bw.
- Executive summary:
Sixteen chelating agents were examined to determine their relative efficacy as antidotes in acute zinc acetate intoxication in mice after i.p. administration. The test substance was not effective at all. It was indicated in this paper that the ip LD50 of the test substance was 3.2 mmol/kg bw (no further details given).
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