Registration Dossier
Registration Dossier
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EC number: 248-122-5 | CAS number: 26942-95-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on microorganisms up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the toxicity of 1,2,3-propanetriyl triisooctadecanoate (CAS 26942-95-0) to aquatic microorganisms are not available. According to Regulation (EC) No. 1907/2006, Annex VIII, Column 2, 9.1.4, testing on aquatic microorganisms is not required if there are mitigating factors indicating that microbial toxicity is unlikely to occur, for example due to high insolubility of the substance in water.
1,2,3-propanetriyl triisooctadecanoate (CAS 26942-95-0) is insoluble in water (WS <0.05 mg/) and therefore limited exposure to activated sludge microorganisms is expected for this substance. The Guidance on information requirements and chemical safety assessment, Chapter R7.b (ECHA, 2012) states that once insoluble chemicals enter a standard STP, they will be extensively removed in the primary settling tank and fat trap and thus, only limited amounts will get in contact with activated sludge organisms.
Furthermore data on the toxicity of the analogue substance 1,2,3-propanetriyl trioleate (CAS 122-32-7) was used as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification section 13. Both substances are characterised by a high C18 fatty acid esters content (>60%) and a low water solubility. The test conducted on 1,2,3-propanetriyl trioleate was performed according to the German method “Assessment of hazardous substances in water, Determination of the acute toxicity in Bacteria”, under GLP conditions. Pseudomonas putida cultures were exposed to the test substance for 18 hours in a static water regime at 25°C and effects on cell proliferation were assessed (as the extinction of the monochromatic radiation at 436 nm in a 10 mm layer). After the exposure period, no inhibitory effects on cell multiplication could be observed up to the highest concentration tested and therefore, the EC50 (18 h) was determined to be > 0.8 mg/L (nominal concentration).
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