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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
unsuitable test system

Data source

Reference
Reference Type:
publication
Title:
About the pharmacologic and toxic activities of E-Caprolactam.
Author:
Hohensee, F.
Year:
1951
Bibliographic source:
Fiber Res. and Textile Tech. 1, 299-303. Cited in: Henschler, D. (Hrsg.), Gesundheitsschaedliche Arbeitsstoffe. Toxikologisch-arbeitsmedizinische Begruendung von MAK-Werten: Caprolactam (1975), 1.-17. Lfg., Verlag Chemie (1991)

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Over a time period of 24 days, 5 and 10% of the test substance was applied daily onto the cornea and the mucosa of the eye (3-4 drops) of 2 animals.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
ε-caprolactam
EC Number:
203-313-2
EC Name:
ε-caprolactam
Cas Number:
105-60-2
Molecular formula:
C6H11NO
IUPAC Name:
azepan-2-one

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
physiological saline
Controls:
not specified
Duration of treatment / exposure:
no data
Observation period (in vivo):
no data
Number of animals or in vitro replicates:
2

Results and discussion

Any other information on results incl. tables

No irritation was observed.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
No irritation was observed in rabbits.
Executive summary:

Over a time period of 24 days, 5 and 10% of the test substance was applied daily onto the cornea and the mucosa of the eye (3-4 drops) of 2 rabbits. No irritation was observed.