Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-313-2 | CAS number: 105-60-2
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- About the pharmacologic and toxic activities of E-Caprolactam.
- Author:
- Hohensee F.
- Year:
- 1 951
- Bibliographic source:
- Faserforschung und Textiltechnik 8, 299-303
Materials and methods
- Principles of method if other than guideline:
- Four guinea-pigs each were dermally exposed (4x6 cm) to 5 and 10 % aqueous solution of Caprolactam daily for 62 days.
Test material
- Reference substance name:
- ε-caprolactam
- EC Number:
- 203-313-2
- EC Name:
- ε-caprolactam
- Cas Number:
- 105-60-2
- Molecular formula:
- C6H11NO
- IUPAC Name:
- azepan-2-one
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Caprolactam
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Duration of treatment / exposure:
- 62 days
- Frequency of treatment:
- daily
Doses / concentrationsopen allclose all
- Dose / conc.:
- 5 other: %
- Remarks:
- solution
- Dose / conc.:
- 10 other: %
- Remarks:
- solution
- No. of animals per sex per dose:
- 4
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No alterations were observed.
No details concerning the applied volume of the test substance, therefore no quantitative assessment possible.
Applicant's summary and conclusion
- Conclusions:
- No alterations were observed.
No details concerning the applied volume of the test substance, therefore no quantitative assessment possible. - Executive summary:
Four guinea-pigs each were dermally exposed (4x6 cm) to 5 and 10 % aqueous solution of Caprolactam daily for 62 days.
No alterations were observed.
No details concerning the applied volume of the test substance, therefore no quantitative assessment possible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
