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EC number: 306-082-7 | CAS number: 95912-86-0
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is readily biodegradable
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Justification for type of information:
- More information about the valididty of the QSAR calculation is given under "Any other information on materials and methods"
- Principles of method if other than guideline:
- Calculation based on HYDROWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- GLP compliance:
- no
- Estimation method (if used):
- - Total Kb for pH > 8: 1.077E-002 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00 - pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 20.398 yr
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- 2.04 yr
- Details on results:
- For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Justification for type of information:
- More information about the valididty of the QSAR calculation is given under "Any other information on materials and methods"
- Principles of method if other than guideline:
- Calculation based on HYDROWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- GLP compliance:
- no
- Estimation method (if used):
- - Total Kb for pH > 8: 1.077E-002 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00 - pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 20.398 yr
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- 2.04 yr
- Details on results:
- For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Justification for type of information:
- More information about the valididty of the QSAR calculation is given under "Any other information on materials and methods"
- Principles of method if other than guideline:
- Calculation based on HYDROWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- GLP compliance:
- no
- Estimation method (if used):
- - Total Kb for pH > 8: 2.369E-002 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00 - pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 9.272 yr
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- 338.674 yr
- Details on results:
- For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Justification for type of information:
- More information about the valididty of the QSAR calculation is given under "Any other information on materials and methods"
- Principles of method if other than guideline:
- Calculation based on HYDROWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- GLP compliance:
- no
- Estimation method (if used):
- - Total Kb for pH > 8: 2.369E-002 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00 - pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 9.272 yr
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- 338.674 yr
- Details on results:
- For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".
Referenceopen allclose all
Result refers to the uncharged molecule.
Result refers to the uncharged molecule.
Result refers to the uncharged molecule.
Result refers to the uncharged molecule.
Description of key information
Hydrolysis is not relevant due to ready biodegradation.
Key value for chemical safety assessment
Additional information
No experimental studies investigating the abiotic hydrolysis fatty acids, C8-10, C12-18-alky esters (CAS 95912-86-0) are available. However, in accordance with Annex VIII, column 2, 9.2.2.1. of Regulation (EC) No 1907/2006, testing is not required since the substance is readily biodegradable. In addition, a supporting QSAR calculation (HYDROWIN v2.00) indicates, that hydrolysis is a negligible pathway for the environmental fate of the test substance in the environment (DT50 > 1 yr (pH 7); Müller, 2011).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
