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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Result is taken from an official NONS dossier and cites an official OECD testing regime so is therefore considered reliable, however the original test report was not available.

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
no
GLP compliance:
not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6-bis(4-ethylphenyl)perhydro-1,3,5,7-tetraoxanaphth-4-ylethane-1,2-diol
EC Number:
406-176-9
EC Name:
2,6-bis(4-ethylphenyl)perhydro-1,3,5,7-tetraoxanaphth-4-ylethane-1,2-diol
Cas Number:
79072-96-1
Molecular formula:
Hill formula: C24 H30 O6
IUPAC Name:
1-[2,6-bis(4-ethylphenyl)-hexahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol

Test animals

Species:
guinea pig
Strain:
other: Albino Guinea Pig (BOR:DHPW:(SPF))
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
olive oil
Duration of exposure:
6 Hours
Doses:
2000 mg/kg
No. of animals per sex per dose:
5 + 2 reserve
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
No deaths were seen in either male or female animals
Clinical signs:
other: No signs of local of systemic toxic effects seen.
Gross pathology:
None

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information
Conclusions:
The LD50 by dermal administration to Guinea Pigs of NC-4 was found to be greater than 2000 mg/kg. No deaths were seen following 6 hours' administration at this dose level.