Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

A skin sensitisation test (Batelle Institut E.V., Frankfurt) was cited in the NONS Registration dossier (Mitsui & Co., Benelux, 1991) for NC-4. The skin sensitisation test was performed by the Buehler method, and according to OECD Test Guideline 406. 20 Guinea pigs (Bor. DHPW (SPF)) were treated dermally with NC-4 in olive oil at a dose level of 2000 mg/kg. Two induction exposures were conducted, followed by a single challenge exposure. A concurrent control group was exposed to untreated vehicle during the induction phase.

No animals showed signs of sensitisation following the challenge exposure.

Migrated from Short description of key information:
Skin sensitisation, guinea pigs (Buehler test) - not sensitising (0 positive responses out of 20 guinea pigs tested).

Justification for classification or non-classification

In a skin sensitisation test conducted in guinea pigs, no animals (out of 20 tested) were found to exhibit signs of sensitisation. On this basis, it is concluded that NC-4 does not meet the criteria for classification as a skin sensitiser.

No data was available regarding respiratory information for NC-4.