Registration Dossier
Registration Dossier
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EC number: 203-639-5 | CAS number: 109-01-3
Endpoint summary
Administrative data
Description of key information
potentially skin sensitising
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
There is no skin sensitization test for 1-methyl piperazine and due to the corrosive properties to the skin, it not considered ethical to perform a skin sensitization test in animals.
For the endpoint skin sensitization a QSAR calculation for test substance was made using the software OASIS TIMES v.2.30.1.11 The model Skin sensitization was used. The substance falls not in the applicability domain of the model. The test substance is considered to be a strong sensitizer but out of domain.
For the endpoint skin sensitization a QSAR calculation for test substance was made using the software Derek Nexus: 6.1.0, Nexus: 2.3.0 (Lhasa Limited). The substance falls in the applicability domain of the model. The test substance is considered to be skin sensitizing.Thus, a classification of Category 1B for skin sensitization based on the EU CLP (GHS) criteria is considered justified.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
There is no skin sensitization test for 1-methyl piperazine available and due to the corrosive properties to the skin, it not considered ethical to perform a skin sensitization test in animals. In silico data (QSAR) support a classification of Category 1B for skin sensitization based on the EU CLP (GHS) criteria.
As there are no data for respiratory sensitisation available, it is concluded that 1-methyl piperazine is not to be classified as a respiratory sensitizer.
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