Registration Dossier
Registration Dossier
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EC number: 201-618-5 | CAS number: 85-60-9
Endpoint summary
Administrative data
Description of key information
Additional information
The biomagnification factor (BMF) of [14C]-6,6’-di-tert-butyl-4,4’-butylidenedi-m-cresol in the fish tissue was determined to be 0.0158 based on an uptake phase of 14 days and a depuration phase of 38 days. The BMF values corrected for growth and lipid were calculated to be 0.0281 and 0.0371, respectively. The results indicated that biomagnification of the test substance in the fish was low when dosed via the diet. Subsequently, the [14C]-6,6’-di-tert-butyl-4,4’-butylidenedi-m-cresol was rapidly depurated from the fish with a half-life of 10.8 days (growth corrected half-life of 19.1 days).
Using the OECD Software tool for OECD 305, the following results were obtained for the 3 methods available:
Method 1: Estimated BCF Range of 14.2 to 158.3
Method 2: Estimated BCF of 28.1
Method 3: Estimated BCF of 684.7.
All 3 values are below the the 2000 L/kg threshold, and the substance is considered to be not bioaccumulative.
Two different QSAR calculations with different models have been performed, and are considered suitable supporting evidence to the full study as follows:
(1) CAESAR: BCF = 41 L/kg
(2) EPISuite BCFBAF: BCF = 758.9 L/kg
Significant accumulation is not to be expected.
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