Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 201-618-5 | CAS number: 85-60-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The substance is not readily biodegradable achieving 2-12% in 28 days. Due to the high water insolubility (<4 μg/l), it is not possible to assess the potential for hydrolysis by testing. The substance is, however a stable organic molecule and is therefore, considered by assessment of structure and experience in use to not hydrolyse in the environment.
The substance is considered to be very persistent in the environment were exposure to occur, based on the known lack of biodegradability.
The bioconcentration factor (BCF) has been calculated as 41 to 758.9 L/kg wet-wt. using QSAR estimation based upon the SMILES code of the molecular structure QSAR model for fish BCF, based on a Radial Basis Function neural network CAESAR v2.1.11 and Arnot-Gobas in EPI Suite.
The partition coefficient was determined to be 6.4. The high log Pow is likely to be due in part to the hydrophobic nature of the molecule.
Furthermore, assessment of the toxicity of the substance shows no dose-related effects at 1000 mg/kg bw/day.
Based on this data the substance is considered to be non-bioaccumulating.
Eco-toxicity studies:
Due to the substance being highly insoluble in water exposure to three aquatic species (algae, daphnia and fish) have been investigated at nominal concentrations. The toxicological examination on fish provided an LC50 >1000 mg/L, on daphnia EC50 >100mg/L and on algae EC50 >100 mg/L.
Mammalian toxicity studies:
The substance has been assessed for genetic toxicity by five in vitro assays with and without metabolic activation, all studies demonstrated a lack of mutagenic response.
The reproduction/developmental screening test produced a NOAEL 1000 mg/kg bw/day with no significant dose-related effects detailed.
The 90-day toxicity feeding study achieved a NOAEL 100ppm.
Considering the toxicological information the substance is not toxic.
The substance may pose a persistence (P) hazard but as the results produced no bioaccumulation (B) or toxicity (T) properties the substance cannot be considered as a PBT / vPvB.
- Likely routes of exposure:
The substance is a powder of a particle size that is not breathable and is generally used in closed conditions.
The likely route of exposure to workers would be by dermal exposure.
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