Registration Dossier
Registration Dossier
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EC number: 203-612-8 | CAS number: 108-74-7
Stability in organic solvents and identity of relevant degradation products
Administrative data
Link to relevant study record(s)
- Endpoint:
- stability in organic solvents and identity of relevant degradation products
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 October 2009 – 09 October 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The test substance was considered stable in DMSO if the relative difference between stored and freshly prepared solutions was ≤ 10%.
- GLP compliance:
- yes (incl. QA statement)
- Test substance stable:
- yes
- Transformation products:
- no
- Conclusions:
- Stock solutions of the test substance were prepared in DMSO at target concentration levels of 0.336, 3.36 and 134 mg/mL. These levels correspond with test substance concentrations of 1, 10 and 400 mg/mL. The solutions were stored at room temperature under normal laboratory light conditions for 0, 1 and 4 hours. Based on the results obtained it was concluded that the DMSO stock solutions at the entire concentration range were stable when stored at room temperature under normal laboratory light conditions for at least 4 hours.
Reference
Description of key information
Stability in DMSO (Oudhoff, 2010): Stable = Yes, Degradation Products = No
Additional information
In a stability study conducted by Oudhoff (2010), the substance was found to be stable in DMSO, with no degradation products formed.
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