Registration Dossier
Registration Dossier
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EC number: 214-029-3 | CAS number: 1073-69-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only limited documentation
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicity of phenylhydrazine in inhalatory exposure
- Author:
- Pham KC
- Year:
- 1 979
- Bibliographic source:
- Gigiena Truda i Professional'nye Zabolevaniya, 3:45-47; cited in WHO 2000, Phenylhydrazine. CICAD 19, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, ISBN 92 4 153019 7; ISSN 1020-6167.
- Reference Type:
- publication
- Title:
- Toxicity of phenylhydrazine in inhalatory exposure
- Author:
- Pham KC
- Year:
- 1 979
- Bibliographic source:
- Gigiena Truda i Professional'nye Zabolevaniya, 3:45-47; cited in BUA (1995) Phenylhydrazine. Stuttgart, S. Hirzel, Wissenschaftliche Verlagsgesellschaft (Report No. 120; ISBN 3-7776-0691-X).
- Reference Type:
- secondary source
- Title:
- Concise International Assessment Document 19: Phenylhydrazine
- Author:
- WHO
- Year:
- 2 000
- Bibliographic source:
- Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, ISBN 92 4 153019 7; ISSN 1020-6167
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
- Principles of method if other than guideline:
- 50 % solution of phenylhydrazine is applicated to the eyes of rabbits.
- GLP compliance:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- no data
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Concentration (if solution): 50 % - Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Irritation
- Basis:
- other: no data
- Time point:
- other: no data
- Score:
- > 0
- Reversibility:
- not specified
- Remarks on result:
- other: The available data clearly indicates that the test substance is irritating to the eye although no scores have been provided.
- Irritant / corrosive response data:
- see remarks on results
- Other effects:
- no data
Any other information on results incl. tables
Applicant's summary and conclusion
- Interpretation of results:
- Category 2A (irritating to eyes) based on GHS criteria
- Remarks:
- Migrated information
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