Registration Dossier
Registration Dossier
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EC number: 214-029-3 | CAS number: 1073-69-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited documentation
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicity of phenylhydrazine in inhalatory exposure
- Author:
- Pham KC
- Year:
- 1 979
- Bibliographic source:
- Gigiena Truda i Professional'nye Zabolevaniya, 3:45-47; cited in BUA (1995) Phenylhydrazine. Stuttgart, S. Hirzel, Wissenschaftliche Verlagsgesellschaft (Report No. 120; ISBN 3-7776-0691-X).
- Reference Type:
- publication
- Title:
- Toxicity of phenylhydrazine in inhalatory exposure
- Author:
- Pham KC
- Year:
- 1 979
- Bibliographic source:
- Gigiena Truda i Professional'nye Zabolevaniya, 3:45-47; cited in WHO 2000, Phenylhydrazine. CICAD 19, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, ISBN 92 4 153019 7; ISSN 1020-6167.
- Reference Type:
- secondary source
- Title:
- Concise International Assessment Document 19: Phenylhydrazine
- Author:
- WHO
- Year:
- 2 000
- Bibliographic source:
- Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, ISBN 92 4 153019 7; ISSN 1020-6167
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
- Principles of method if other than guideline:
- Determination of LC50 values for an unstated exposure period.
- GLP compliance:
- no
- Test type:
- other: Inhalation procedure with whole body exposure
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- no data
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: no data
- Details on inhalation exposure:
- no data
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks on duration:
- no data
- Concentrations:
- No data about the tested concentrations. According to the original publication LC50 was 2.61 +/- 0.37 mg/L.
Cited in WHO 2000, LC50 was determined as 2745 mg/m³ (610 ppm).
Cited in UBA 1994, LC50 was identical to the original publication (2.61 +/- 0.37 mg/L). - No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- No statistics was performed.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 2.61 mg/L air
- Remarks on result:
- other: no data about exposure duration
- Mortality:
- no details
- Clinical signs:
- other: respiratory disorder such as other methemoglobin formers
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
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