Registration Dossier
Registration Dossier
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EC number: 700-280-0 | CAS number: 1869-24-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-(trifluoromethyl)benzene-1-sulfonamide
- EC Number:
- 700-280-0
- Cas Number:
- 1869-24-5
- Molecular formula:
- C7H6F3NO2S
- IUPAC Name:
- 2-(trifluoromethyl)benzene-1-sulfonamide
- Reference substance name:
- 2-(Trifluoromethyl)benzenesulfonamide
- IUPAC Name:
- 2-(Trifluoromethyl)benzenesulfonamide
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- other: Negative control: Untreated skin sites of the same animal
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- Animals 1,2,3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.1
- Max. score:
- 0.3
- Reversibility:
- fully reversible
- Remarks:
- 48 hours
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- Animals 1,2,3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The TS does not give indication of an irritant property to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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