Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1994

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Qualifier:
according to guideline
Guideline:
EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(trifluoromethyl)benzene-1-sulfonamide
EC Number:
700-280-0
Cas Number:
1869-24-5
Molecular formula:
C7H6F3NO2S
IUPAC Name:
2-(trifluoromethyl)benzene-1-sulfonamide
Constituent 2
Reference substance name:
2-(Trifluoromethyl)benzenesulfonamide
IUPAC Name:
2-(Trifluoromethyl)benzenesulfonamide

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
other: comminuted test substance
Controls:
other: Negative control: Untreated eye
Duration of treatment / exposure:
Indeterminate duration/ 72 hours
Observation period (in vivo):
72 hours
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: Cornea, Iris, Chemosis
Basis:
other: Average score
Time point:
other: 24 to 72 hours
Score:
0
Irritation parameter:
conjunctivae score
Basis:
other: average score
Time point:
other: 24 to 72 hours
Score:
0.1
Reversibility:
fully reversible within: 48 hours

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The TS does not give indication of an irritant property to the eye.