N-tert-butylacrylamide

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species, other

Remarks:

Fish

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

Estimated data generated using the EPI Suite program developed by the USEPA.

Qualifier:

according to guideline

Guideline:

other: Modeling database

Principles of method if other than guideline:

Prediction done using BCFBAF (v3.01) model

GLP compliance:

not specified

Radiolabelling:

not specified

Vehicle:

not specified

Test organisms (species):

other: Fish

Route of exposure:

aqueous

Test type:

not specified

Water / sediment media type:

natural water: freshwater

Test temperature:

25 deg.C

Reference substance (positive control):

not specified

Key result

Temp.:

25 °C

Type:

BCF

Value:

2.19 L/kg

Basis:

whole body w.w.

Calculation basis:

other: estimated

Remarks on result:

other: Non-bioaccumulative

BCFBAF Program (v3.01) Results:

==============================

SMILES : O=C(NC(C)(C)C)C=C

CHEM : 2-Propenamide, N-(1,1-dimethylethyl)-

MOL FOR: C7 H13 N1 O1

MOL WT : 127.19

--------------------------------- BCFBAF v3.01 --------------------------------

Summary Results:

Log BCF (regression-based estimate): 0.34 (BCF = 2.19 L/kg wet-wt)

Biotransformation Half-Life (days) : 0.0388 (normalized to 10 g fish)

Log BAF (Arnot-Gobas upper trophic): 0.19 (BAF = 1.55 L/kg wet-wt)

Log Kow (experimental): not available from database

Log Kow used by BCF estimates: 1.02

Equation Used to Make BCF estimate:

Log BCF = 0.6598 log Kow - 0.333 + Correction

Correction(s): Value

No Applicable Correction Factors

Estimated Log BCF = 0.340 (BCF = 2.19 L/kg wet-wt)

Validity criteria fulfilled:

not specified

Conclusions:

Using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for test chemical is 2.19 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemica is nonbioaccumulative in food chain.

Executive summary:

Using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for test chemical  is 2.19 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemica is nonbioaccumulative in food chain.

Description of key information

Using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for test chemical  is 2.19 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemica is nonbioaccumulative in food chain.

Key value for chemical safety assessment

BCF (aquatic species):

2.19 L/kg ww

Additional information

Different studies have been conducted for test chemical and its read across chemical for bioaccumulation in aquatic organisms endpoint and their results are summarized below.

The first study was done by using BCFBAF Program (v3.00) model of EPI suite (2018) and bio concentration factor (BCF) for test chemical  was estimated to be 2.19 L/kg wet-wt at 25 deg. c
 

Next study was reviewed from authoritative database (HSDB) in this study the BCF value of test chemical estimated was 3.0 dimensionless by using an estimated log Kow of 0.57 and a regression-derived equation and it is far less than 2000 criteria of CLP regulation.

By considering both studies mentioned above it is concluded that test chemical is non bioaccumulative.

Bioaccumulation endpoint can also be considered for waiver inaccordance with column 2 of Annex IX of the REACH regulation, testing for this endpoint is scientifically not necessary and does not need to be conducted since the test chemical has a low potential for bioaccumulation based on logKow ≤ 3.