Registration Dossier
Registration Dossier
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EC number: 203-505-6 | CAS number: 107-58-4
Endpoint summary
Administrative data
Description of key information
Bioaccumulation : aquatic/sediments:
Using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for test chemical is 2.19 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemica is nonbioaccumulative in food chain.
Additional information
Bioaccumulation : aquatic/sediments:
Different studies have been conducted for test chemical and its read across chemical for bioaccumulation in aquatic organisms endpoint and their results are summarized below.
The first study was done by using BCFBAF
Program (v3.00) model of EPI suite (2018) and bio
concentration factor (BCF) for test chemical was estimated to be 2.19
L/kg wet-wt at 25 deg. c
Next study was reviewed from authoritative database (HSDB) in this study the BCF value of test chemical estimated was 3.0 dimensionless by using an estimated log Kow of 0.57 and a regression-derived equation and it is far less than 2000 criteria of CLP regulation.
By considering both studies mentioned above it is concluded that test chemical is non bioaccumulative.
Bioaccumulation endpoint can also be considered for waiver inaccordance with column 2 of Annex IX of the REACH regulation, testing for this endpoint is scientifically not necessary and does not need to be conducted since the test chemical has a low potential for bioaccumulation based on logKow ≤ 3.
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