Registration Dossier
Registration Dossier
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EC number: 938-828-8 | CAS number: 1463474-95-4
Endpoint summary
Administrative data
Description of key information
HBED-Fe is not expected to be harmful to aquatic organisms based on read across from EDDHMA-Fe (structural analogue). This is confirmed by the results observed in the long term daphnia test with HBED-Fe where no effects upto 96.6 mg a.i./L were observed for reproduction or parental mortality.
The results as observed for algae should be considered with case due to the chelating properties and coloration of the test solutions.
Additional information
Not all data are available for the substance itself, however sufficent reliable data are also available from structurally similar substances and the actual test substance to allow a conclusion on the ecotoxicity of HBED-Fe (see also read across justification in section 13 of IUCLID).
Fish:
The acute toxic effects of EDDHMA-Fe to fish were investigated in studies according to the principles of OECD-Guideline 203 and EU method C.1. The LC50 for a 96 hour exposure was greater than 1000 mg/L for rainbow trout and carp.
Daphnia:
The acute toxic effects of EDDHMA-Fe (a structurally similar material as HBED-Fe) to Daphnia magna were investigated according to the principles of OECD-Guideline 202 and EU method C.2. The EC50 for a 48 hour exposure was 4.6 g/L.
In a long-term daphnia study according to OECD 211 with EDDHMA-Fe, no effects on the survival of Daphnia magna at concentrations up to and including 1000 mg/L were observed. In the same study a NOEC of 320 mg/L for reproduction could be derived.
As bridging study a long term daphnia study according to OECD 211 with HBED-Fe (CAS no: 1463474 -95 -4) was performed and as expected no effects were observed at 100 mg/L (96.6 mg a.i./L) for any of the tested endpoints.
Algae:
The 72 hour ErC50 value for EDDHMA-Fe with the Selenastrum capricornutum was 71 mg/L and the ErC10 was 2.8 mg/L.
However, due to the chelating properties and coloration of the test solutions, results on algae should be considered with care. The end-point for aquatic plants is likely more representative of actual toxic effects.
Aquatic plants:
In a guideline study on the acute toxicity of EDDHMA-Fe to Lemna minor the EC50-values for inhibition of log biomass growth (EbC50), specific growth rate (ErC50) and log biomass dry weight (EdwC50) were all > 184.2 mg/L, the NOEC was 184.2 mg/L and the LOEC was > 184.2 mg/L.
Microorganisms:
The 3 hours EC10 value for the (read across) test substance EDDHA-FeNa in the Activated Sludge Respiration Inhibition Test was 450 mg/L. The EC50 was greater than 1000 mg/L. Recalculated based on molecular mass correction this would give for EDDHMA-Fe 477 mg/L and > 1060 mg/L for EC10 and EC50 value respectively.
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