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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1993
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: study performed under GLP and in accordance with OECD-/EU-testing guidelines

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Report date:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Principles of method if other than guideline:
Method B.3: Acute toxicity (dermal)

Regulation of Czech Ministry of Health No.251/1998.


Method is identical with method:

Method B.3 Acute toxicity (dermal)

Directive 67/548/EEC, Annex V, Part B: Methods for the
determination of toxicity. Published in OJ L 383 A 1992.
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1

Test animals

Species:
other: Wistar rat

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: No vehicle. The sample was used as such.
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 150 mg/kg bw
Mortality:
Male: 2150 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2150 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: No effects
Gross pathology:
Effects on organs:
No effects.
Other findings:
Signs of toxicity (local):
The increase of the weight of the animals during 14 days
after application was physiological (males and females).

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU