Registration Dossier
Registration Dossier
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EC number: 202-844-7 | CAS number: 100-36-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-aminoethyldiethylamine
- EC Number:
- 202-844-7
- EC Name:
- 2-aminoethyldiethylamine
- Cas Number:
- 100-36-7
- Molecular formula:
- C6H16N2
- IUPAC Name:
- N1,N1-Diethyl-1,2-ethanediamine
- Details on test material:
- Name of the test substance used in the study report: N,N-Diethyl-ethylendiamin
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- A standardized animal laboratory diet was used.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- Concentrations: 0.5 and 2.0% (G/V)
Application volume: 10 ml/kg - Doses:
- 50, 200 mg/kg
- No. of animals per sex per dose:
- 5
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 50 - < 200 mg/kg bw
- Mortality:
- 50 mg/kg: 0/5 after 14 days, 100 mg/kg: 5/5 after 14 days (male and female animals)
- Clinical signs:
- dyspnea, apathy, trembling, spastic gait, urine intense yellow, ruffled fur, exsiccosis, poor general state.
- Body weight:
- Mean body weights of male animals: at study start: 24 g (50 and 200 mg/kg), after 13 d 31.6 g (50 mg/kg).
Mean body weights of female animals: at study start: 22 g (50 and 200 mg/kg); after 13 d 25.4 g /50 mg/kg). - Gross pathology:
- Animals that died and sacrificed animals: no intra-abdominal substance residues nor adhesions.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
