Registration Dossier
Registration Dossier
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EC number: 209-128-3 | CAS number: 556-52-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In the first study (Klein 1978), Leuciscus idus melanotus were exposed to Glycidol, 2,3-epoxipropanol. The following concentrations were used: Product solution 1 mL/L water; Dilution - 500 mL/L, 1:1; Dilution 250 mL/L, 1:4; and Dilution 125 mL/L, 1:8. The fish were exposed to the test material for a period of 48 hours in static conditions. Based on the results of this experiment, as the LC0 is greater than 100 mg/L, it is thought that the substance 2,3 -epoxypropanol (glycid) is not toxic to the aquatic environment.
In the second study (Anon. 1978) Leuciscus idus melanotus were exposed to Glycidol, 2,3-epoxipropanol for a period of 48 hours. The test animals didn’t show any toxic effects after an exposure period of 48 hours. This study was not considered to be reliable due to methodological deficiencies.
Two QSAR reports have been provided as supporting data for the short-term toxicity of 2,3 -epoxypropanol (glycid) to fish. ECOSAR and OECD (Q)SAR were used. The two QSAR models which were run used the following chemical input data:
Input Chemical Name: Oxiranemethanol
ECOSAR Class: mono epoxide and a neutral organic chemical
SMILES notation: O(C1CO)C1
Using ECOSAR, as the lethal toxicity of the epoxide chemical class is the worst case for this estimated value the fish LC50was determined to be 333.48 mg/L (Brady, 2010a).
Using OECD (Q)SAR Toolbox, as the lethal toxicity of the mono epoxide class was the worst case, the LC50was found to be 50.1 mg/L (Brady, 2010b).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 50.1 mg/L
Additional information
Based on the prediction results described above and as the substance is readily biodegradable, the substance 2,3-Epoxypropanol (Glycid) is not classified for toxicity to the aquatic environment according to Regulation (EC) No. 1272/2008 or Directive 67/548/EEC.
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