Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-128-3 | CAS number: 556-52-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Two QSAR reports were also supplied. ECOSAR was used to estimate the toxicity of 2,3-Epoxypropanol (Glycid) to Daphnia. As the lethal toxicity of epoxide chemical class for Dapnia is the worst case for this estimated value, a 48 EC50 for Daphnia 2,176.81 mg/L was determined (Brady, 2010a).
OECD (Q)SAR (epoxides, mono neutral organic SAR (Baseline Toxicity)) was used to estimate the acute toxicity of 2,3-Epoxypropanol (Glycid) to Daphnia. The 48 EC50was estimated to be 334 mg/L (Brady, 2010b).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 334 mg/L
Additional information
Two QSAR reports have been provided to address the acute toxicity of 2,3-epoxypropanol (Glycid) to aquatic inverterates, one was generated using ECOSAR and the other using OECD QSAR Toolbox.
ECOSAR was used to estimate the toxicity of 2,3-Epoxypropanol (Glycid) to Daphnia. As the lethal toxicity of epoxide chemical class for Daphnia's the worst case for this estimated value, a 48 EC50 for Daphnia 2,176.81 mg/L was determined (Brady, 2010a).
OECD (Q)SAR (epoxides, mono neutral organic SAR (Baseline Toxicity)) was used to estimate the acute toxicity of 2,3-Epoxypropanol (Glycid) to Daphnia. The 48 EC50 was estimated to be 334 mg/L (Brady, 2010b).
Based on the prediction results described above and as the substance is readily biodegradable, the substance 2,3-Epoxypropanol (Glycid) is not classified for toxicity to the aquatic environment according to Regulation (EC) No. 1272/2008 or Directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
