6,6'-di-tert-butyl-4,4'-butylidenedi-m-cresol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

07 May 2012 to 06 July 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study performed in accordance with OECD, EU & US EPA test guidance in compliance with GLP

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

GLP compliance:

yes

Type of method:

column elution method

Water solubility:

< 4 µg/L

Temp.:

20 °C

pH:

7.8 - 7.9

Details on results:

The turbidity of the eluates was < 0.2 NTU. According to this, no undissolved particles were detected in the eluates. The test substance signal in the samples from the blank column was below that of the lowest calibration standard.
In most of the samples a (small) test substance peak was detected which was below the lowest calibration standard (2 μg/l). The concentration for these samples was reported as below the lowest standard which leads to < 4 μg/l taking the dilution factor of the samples (2) into account. Since a (small) test substance peak was detected in most of the samples, it was clear that test substance remained in the column throughout the test.
After performance of the test, the column material was checked by chemical analysis. It was demonstrated that the column material still contained the test substance (results are archived in the raw data).

Main study – water solubility of the test substance

Flow rate [ml/h]	Sample no.	Concentration analysed					pH
		Individual [μg/l]	Mean^1[μg/l]	CV [%]	Mean^2[μg/l]	MD [%]
24	1	< 4^3	< 4	n.a.	< 4	n.a.	7.9
	2	< 4^3
	3	< 4^3
	4	< 4^3
	5	< 4^3
	6	< 4^3
	7	< 4^3
	8	< 4^3
	9	< 4^3
	10	< 4^3
12	1	< 4^3	< 4	n.a			7.8
	2	< 4^3
	3	< 4^3
	4	< 4^3
	5	< 4^3
	6	< 4^3
	7	< 4^3
	8	< 4^3
	9	< 4^3
	10	< 4^3

¹Mean of the concentrations obtained at one flow rate.

²Mean of the concentration obtained at both flow rates.

³Based on the response of the lowest calibration standard and taking the diluting factor of the sample into account.

n.d. Not detected.

n.a. Not applicable.

Conclusions:

Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility of the test substance at 20°C was < 4 μg/l.

Executive summary:

Study performed in accordance with European Community (EC), EC no. 440/2008, Part A: Methods for the Determination of Physico-Chemical Properties, Guideline A.6: “Water Solubility”, OECD Guidelines for the Testing of Chemicals no. 105: "Water Solubility", United States Environmental Protection Agency (EPA), Product Properties Test Guidelines no. OPPTS 830.7840: "Water Solubility: Column Elution Method; Shake Flask Method", March 1998 and in compliance with the Principles of Good Laboratory Practice (GLP).

The column elution method was applied for the determination of the water solubility of 6,6’-di-tert-butyl-4,4’-butylidenedi-m-cresol.

The water solubility of the test substance at 20°C was < 4 μg/l.

Description of key information

Key value determined by experimental method utilising OECD, EU & US EPA test guidance.

The water solubility of the test substance at 20°C was < 4 μg/l.

Key value for chemical safety assessment

Water solubility:

4 µg/L

at the temperature of:

20 °C