Registration Dossier
Registration Dossier
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EC number: 700-224-5 | CAS number: 1647-12-7
Endpoint summary
Administrative data
Description of key information
ORAL
LD50 (rat) > 2000 mg/kg bw (acute toxic class method; OECD TG 423) (BASF SE, 2009).
No classification / labeling required.
DERMAL and INHALATION
No data are available.
Key value for chemical safety assessment
Additional information
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Oral LD50 Females > 2000 mg/kg bw
(Limit Test; no mortality occurred; no clinical symptoms were observed) - Oral LD50 Combined > 2000 mg/kg bw (calculated)
ORAL
In an acute oral toxicity study (BASF, 2009), groups of fasted, approximately 10-week old, female Wistar rats were given a single oral dose of unchanged, liquid 2-Methylbuten-3-säureethylester (ca. 99% pure) at a dose of 2000 mg/kg bw (two groups of 3 animals) according to the acute toxic class procedure. After dosing, the animals were observed for 14 days. The study was carried out in accordance with the test guidelines OECD 423, EU B.1, OPPTS 870.1100, and Japan MAFF 8147.
2-Methylbuten-3-säureethylester is of LOW Toxicity based on the LD50 in females.
No deaths and no clinical signs of toxicity were observed in any group. There was no adverse effect on body weight gain, and there were no macroscopic pathological findings.
DERMAL and INHALATION
No data are available.
Justification for classification or non-classification
Based on the LD50 exceeding 2000 mg/kg bw and on the lack of mortality and specific clinical symptoms, there is no need to classify 2-Methylbuten-3-säureethylester for acute oral toxicity according to the Directive 67/548/EC and according to the GHS criteria.
Reliable data on acute toxicity via the oral route of exposure are available. Thus, according to the articles 10(a) and 12(1) in connection with Annex VII-X of REACH-data on the acute toxicity via the inhalation and dermal route is not required.
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