Registration Dossier
Registration Dossier
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EC number: 610-147-8 | CAS number: 438056-69-0
Endpoint summary
Administrative data
Description of key information
Oral by gavage, subacute (4 weeks) (Rat-Wistar, GLP, OECD TG 407, EU Method B. 7): NOAEL = 40 mg/kg body weight
[Bayer AG, Report No. PH-34876, 2007-04-20]
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 40 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
Anilinomorpholinon was administered orally by gavage to 10 male and female Wistar rats per dose group, in doses of 0, 0.1, 2 and 40 mg/kg body weight for a period of 28 (males)/29 (females) days. The animals were regularly observed and weighed. Food and water intakes were determined. Clinical laboratory investigations of blood samples were performed. Organs and tissues were subjected to gross and histopathological investigation. Selected organs were weighed. No treatment-related adverse effects were observed up to and including the highest dose administered and therefore, the NOAEL for Anilinomorpholinon given orally by gavage was established at 40 mg/kg in male and female rats.
Justification for classification or non-classification
Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.
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