Registration Dossier
Registration Dossier
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EC number: 610-147-8 | CAS number: 438056-69-0
Endpoint summary
Administrative data
Description of key information
Skin corrosion in vitro (3D-skin model with EST-1000, GLP, OECD TG 431 guideline draft, EU Method B.40): not corrosive
[Bayer AG, Report No. PH-34734, 2007-01-16]
Skin irritation in vivo (Rabbit-NZW, GLP, OECD TG 404, EU Method B.4): not irritating to the skin
[Bayer AG, Report No. PH-34641, 2006-10-27]
Eye irritation in vivo (Rabbit-NZW, GLP, OECD TG 405, EU Method B.5): not irritating to the eye
[Bayer AG, Report No. PH-34642, 2006-10-27]
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
In the skin corrosion test in vitro with reconstructed human epidermis EST-1000 no corrosive property of the test item could be determined.
In the skin irritation test in all 3 animals no signs of skin irritation could be observed after 48 and 72 h. One animal showed slight erythema (grade 1) up to 24 h after administration which was fully reversible within 2 days. There were no systemic intolerance reactions.
In the eye irritation test all animals showed reddening of the conjunctivae 1 h after instillation (grade 2). 2 of them had also slight irritation signs at the conjunctivae after 24 h. One animal showed corneal opacity as well as redness and chemosis of the conjunctivae up to 48 h after administration. All effects were fully reversible within 2 -3 days. There were no systemic intolerance reactions.
Justification for classification or non-classification
Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.
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