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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24/09/19 to 10/10/19
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
July 27, 1995.
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
March 04, 2016.
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
March 1998
Deviations:
no
GLP compliance:
yes
Type of method:
column elution method

Test material

Constituent 1
Test material form:
solid: particulate/powder

Results and discussion

Water solubility
Key result
Water solubility:
< 0.002 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
7.4 - 7.6

Any other information on results incl. tables

Main study - water solubility of the test item
Flow rate Sample n° Concentration analyzed pH pH
  Individual Mean (1) CV Mean (2) MD
mL/h mg/L mg/L % mg/L %
24 1 < 0.0016 < 0.0016 n.a < 0.0016 n.a 7,6
2 < 0.0016  
3 < 0.0016  
4 < 0.0016  
5 < 0.0016  
6 < 0.0016  
7 < 0.0016  
8 < 0.0016  
9 < 0.0016  
10 < 0.0016  
12 1 < 0.0016 < 0.0016 n.a 7,4
2 < 0.0016  
3 < 0.0016  
4 < 0.0016  
5 < 0.0016  
6 < 0.0016  
7 < 0.0016  
8 < 0.0016  
9 < 0.0016  
10 < 0.0016        
1 Mean of the concentrations obtained at one flow rate.     
2 Mean of the concentrations obtained at both flow rates.  
n.a. not applicable

Applicant's summary and conclusion

Conclusions:
The column elution method was applied for the determination of the water solubility of the product
The water solubility of the test item at 20°C was <0.0016 mg/L.
The pH of the aqueous samples was 7.4 and 7.6.
Executive summary:

In the study (CRL 2019) the water solubility was determined with column elution method.

The water solubility of the test item at 20°C was <0.0016 mg/L. (pH 7.4 -7.6)