Registration Dossier
Registration Dossier
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EC number: 431-480-3 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08/01/18 to 01/03/18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- April 13, 2004.
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- 4.1
- Temp.:
- 25 °C
- pH:
- 7
Any other information on results incl. tables
| Pow of the Test Item | |||||
| Substance | Retention time (min) | log Pow | Pow | ||
| tr,1 | tr,2 | mean | |||
| Formamide (t0) | 0.597 | 0.595 | 0.596 | ||
| Bromobenzene | 1.577 | 1.577 | 3.0 | ||
| 1,4-Dichlorobenzene | 1.963 | 1.964 | 3.4 | ||
| Biphenyl | 2.641 | 2.644 | 4.0 | ||
| 1,2,4-Trichlorobenzene | 3.042 | 3.046 | 4.2 | ||
| Dibenzyl | 4.395 | 4.405 | 4.8 | ||
| Triphenylamine | 8.110 | 8.116 | 5.7 | ||
| Test item – peak 1 | 2.838 | 2.843 | 2.841 | 4.1 | 1.2 *10E4 |
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient(n-octanol/water) of test substance was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was found to be 4.1 at 25°C.
- Executive summary:
The partition Coefficient n-octanol/water was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals .
The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared.
The reference substances were formaldehyde, bromobenzene, 1,4 -dichlorobenzene, biphenyl, 1,2,4 -trichlorobenzene, dibenzyl, triphenylamine, having Pow value ranging from 0.3 to 5.7.
The Log Pow value was found to be 4.1 at 25°C.
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