Registration Dossier
Registration Dossier
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EC number: 239-263-3 | CAS number: 15206-55-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non standard test design, with little reporting detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Inhalation-Risk-Test was performed in principle as described in OECD Guideline 403. It demonstrates the toxicity of an atomosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation (20°C and 60°C).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl benzoylformate
- EC Number:
- 239-263-3
- EC Name:
- Methyl benzoylformate
- Cas Number:
- 15206-55-0
- Molecular formula:
- C9H8O3
- IUPAC Name:
- methyl oxo(phenyl)acetate
- Details on test material:
- - Physical state: liquid (tested were vapours at 20 and 60°C)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean: male: 171 g; female: 158 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Source and rate of air: 200L air/h
- System of generating test atmospere: Vapor is generated by bubbling 200 L/h air at 20°C and 100 L/h air at 60°C through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 7 hours.
- Pressure in air chamber: 760 mm/Hg - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 7 h
- Concentrations:
- not determined
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily, weighing at beginning and at the end of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- other: vapours formed at 20°C and 60°C
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Mortality:
- none
- Clinical signs:
- other: none
- Gross pathology:
- no abnormalities detected
Applicant's summary and conclusion
- Interpretation of results:
- other: vapours at 20°C and 60°C are not acutely toxic
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