Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 405-370-0 | CAS number: 6334-25-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Based on the results after single oral administration of (C)-Lunamer 552 to male and female rats at two dose levels as well as after repeated oral administration of unlabelled test substance followed by (C)-Lunamer 552 at the low dose level to male and female rats, the conclusion are:
Excretion occured in all groups rapidly mainly via faeces. Within 48 hours, the radioactivity was almost completely excreted. At 96 hours after the administration, radioactive residues in organs/tissues were very low.
Concerning pharmacokinetic parameters, no difference between male/female rats, low/high dose as well as single/repeated administration were found.
The major amount of the radioactivity in the faeces could be extracted by using acetonitrile/purified water ( 8+2, v/v). In faeces up to 6 radioative fractions (F1-F6) were detected. F2 was identical to the parent item. Fractions F1, F3-F6 were unknown metabolite fractions.
In urine at least 4 radioactive fractions(U1-U4) were detected. U1 was identical to the parent item. Fractions U2-U4 were unknown metabolite fractions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
