Registration Dossier
Registration Dossier
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EC number: 405-370-0 | CAS number: 6334-25-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study already evaluated and accepted by national autorities. Information from migrated NONS file as per inquiry # [06-0000021278-68-0000].
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (Limit test)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- -
- EC Number:
- 405-370-0
- EC Name:
- -
- Cas Number:
- 6334-25-4
- Molecular formula:
- C14H28N2O6
- IUPAC Name:
- N,N,N',N',-tetrakis(2-hydroxyethyl)hexanediamide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl: CDBr
Administration / exposure
- Vehicle:
- other: Distilled water
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- Male: 0 mg/kg; number of animals: 6; number of death: 0
Male: 5000 mg/kg; number of animals: 6; number of death: 0
Female: 0 mg/kg; number of animals: 6; number of death: 0
Female: 5000 mg/kg; number of animals: 6; number of death: 0 - Clinical signs:
- Sign of toxicity related to dose levels:
No deaths were observed. Diarrhoea was noted at 4 hours in the test group - Gross pathology:
- Effects on organs:
No treatment-related macroscopic findings were observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: EU
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