Registration Dossier
Registration Dossier
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EC number: 610-200-5 | CAS number: 446292-07-5
Endpoint summary
Administrative data
Description of key information
Skin corrosion in vitro (3D-skin model with EST-1000, GLP, OECD TG 431 guideline draft, EU Method B.40): not corrosive
[Bayer AG, Report No. PH-34723, 2007-01-11]
Skin irritation in vivo (Rabbit-NZW, GLP, OECD TG 404, EU Method B.4): not irritating to the skin
[Bayer AG, Report No. PH-34716, 2007-01-08]
Eye irritation in vivo (Rabbit-NZW, GLP, OECD TG 405, EU Method B.5): not irritating to the eye
[Bayer AG, Report No. PH-34401, 2006-04-10]
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
In the skin corrosion test in vitro with reconstructed human epidermis EST-1000 no corrosive property of the test item could be determined.
In the skin irritation test in all 3 animals no signs of skin irritation could be observed. There were no systemic intolerance reactions.
In the eye irritation test all animals showed reddening of the conjunctivae 1 h after instillation; one animal additionally showed slight chemosis. Only 2 of them had slight irritation signs at the conjunctivae after 24 h and after 24 -48 h, respectively . All effects were fully reversible within 2 -3 days. There were no systemic intolerance reactions.
Justification for classification or non-classification
Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.
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