Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study with acceptable restrictions

Data source

Reference
Reference Type:
other: ECHA inquiry result
Title:
Unnamed
Year:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 401
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
413-060-1
EC Name:
-
Cas Number:
19186-97-1
Molecular formula:
C15H24O4PBr9
IUPAC Name:
tris[3-bromo-2,2-bis(bromomethyl)propyl] phosphate

Test animals

Species:
other: Spraque-Dawley Rat

Administration / exposure

Vehicle:
corn oil

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
Male: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
The only clinical signs were chromorhinorrhea, diarrhea,
chromodacryorrhea and abdominogenital staining. These
clinical signs were noted only in the first 6 hours after
treatment.
Gross pathology:
Effects on organs:
No treatment-related organ effects

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU