Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-839-5 | CAS number: 127-39-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study is performed in male animals only, with a +-45% active ingredient formulation, and not under GLP compliance. The study is conducted similar to OECD standard and shows consistent results, therefore the study is considered to be adequate, reliable and relevant.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- No. animals
- Principles of method if other than guideline:
- Only male rats were used.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium 1,2-diisobutoxycarbonylethanesulphonate
- EC Number:
- 204-839-5
- EC Name:
- Sodium 1,2-diisobutoxycarbonylethanesulphonate
- Cas Number:
- 127-39-9
- Molecular formula:
- C12H22O7S.Na
- IUPAC Name:
- sodium 1,4-diisobutoxy-1,4-dioxobutane-2-sulfonate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): AEROSOL® IB, Sodium di-iso-butyl sulfosuccinate
- Physical state: Not provided
- Analytical purity: 44-46 %
- Impurities (identity and concentrations): See confidential details
- Composition of test material, percentage of components: See confidential details
- Purity test date: Not provided
- Lot/batch No.: Not provided
- Expiration date of the lot/batch: Not provided
- Stability under test conditions: Not provided
- Storage condition of test material: Not provided
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Not provided
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% w/v - Doses:
- 10.0g/kg, 5.0 g/kg and 2.5 g/kg
- No. of animals per sex per dose:
- 5 male rats per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Body weight: initial & terminal
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 160 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 4 660 - 8 120
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 772 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- 2 097 - 3 654
- Mortality:
- 5/5 in the 10.0 g/kg group
1/5 in the 5.0 g/kg group
0/5 in the 2.5 g/kg group - Clinical signs:
- other: Motor ataxia, dyspnea, comatose, and death within 1 hour at 10 g/kg
- Gross pathology:
- Decedents: mucosa of stomach and intestines extremely hyperemic
Survivors: normal
Any other information on results incl. tables
Table 1. Body weights & clinical signs
Dosage |
Onset of (S) Signs, (D) Death, Hours and Days |
Died/Dosed |
MEAN WT |
Time of (R) Recovery, Days |
|||||||||||||||
0-6 |
6-24 |
2 |
3 |
4 |
5 |
6 |
7 |
8-14 |
|
I |
T |
1 |
2 |
3 |
4 |
5 |
6 |
7-14 |
|
10.0 g/kg |
SD5 |
|
|
|
|
|
|
|
|
5/5 |
103 |
- |
|
|
|
|
|
|
|
5.0 g/kg |
|
|
|
|
D1 |
|
|
|
|
1/5 |
106 |
221 |
|
|
|
|
|
|
|
2.5 g/kg |
|
|
|
|
|
|
|
|
|
0/5 |
105 |
219 |
|
|
|
|
|
|
|
I: initial; T: terminal
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A mortality of 5/5 at a dosage of 20g/kg was assumed for calculation of the rat oral LD50.
The rat oral LD50 is calculated to be 6160mg/kg, corresponding to 2772 mg act.ingr./kg. - Executive summary:
Oral acute toxicity was tested in 5 male albino Wistar rats/group with a test item containing 44 -46% active ingredient at 10, 5 and 2.5 g/kg bw (4500; 2250 and 1125 mg act.ingr./kg bw). In the high dose group all 5 animals died within 6 hours after dosing. In the mid dose group 1 of 5 animals died on day 4; in the low dose group all animals survived. Clinical neurological signs were observed at the highest dose only and gross autopsy showed extremely hyperemic mucosa of stomach and intestines in the decedents, whereas survivors were normal. The LD50 was calculated to be 6160 mg/kg, corresponding to 2772 mg act.ingr./kg
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
