Registration Dossier
Registration Dossier
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EC number: 300-344-4 | CAS number: 93925-42-9
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Type of information:
- experimental study planned
- Justification for type of information:
- OECD 473 shows cytotoxicity and chromosome aberation. Therefore, according to Regulation (EC) No. 1907/2006 an OECD 475 study is required.
- Available GLP studies
no studies avaible for the substance
- Available non-GLP studies
no studies avaible for the substance
- Grouping and read-across
no studies avaible for possible read across substances
- Historical human data
no historical human data avaible
- (Q)SAR
out of prediction range, Regulation requires in vivo study
- In vitro methods
Regulation requires in vivo study
- Weight of evidence
not possible based on data lacking
- Substance-tailored exposure driven testing [if applicable]
n.a.
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
- Deviations:
- no
Test material
- Reference substance name:
- Silicic acid (H4SiO4), tetraethyl ester, reaction products with bis(acetyloxy)dibutylstannane
- EC Number:
- 300-344-4
- EC Name:
- Silicic acid (H4SiO4), tetraethyl ester, reaction products with bis(acetyloxy)dibutylstannane
- Cas Number:
- 93925-42-9
- Molecular formula:
- C12H24O4Sn.C8H20O4Si
- IUPAC Name:
- Acetic acid, 1,1'-(dibutylstannylene) ester, reaction products with silicic acid (H4SiO4) tetra-Et ester
- Details on test material:
- UL03475
Constituent 1
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
