Registration Dossier
Registration Dossier
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EC number: 464-520-3 | CAS number: 189813-45-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
In the key study (BASF AG, 2000) performed according to OECD guideline 406 (Skin Sensitization) and GLP, sensitizing effect on the skin of the guinea pig was tested in the Maximization Test. The induction was performed intradermally and epicutaneously with 5 and 50% test substance preparation, respectively. Two challenges were performed 14 and 21 days after the epicutaneous induction. After the challenges with a 25% test substance preparation in olive oil discrete or patchy erythema to moderate and confluent erythema, swelling and scaling were observed in some test group animals. While the skin reactions observed in two test group animals after the first challenge were reproducible by the 2nd challenge, the third animal with reactions after first challenge did not show any skin effects after 2nd challenge. However, another animal was observed with skin effects after the 2nd challenge in the test group. In addition the skin reactions observed in 2 animals of control group after the 2nd challenge application i.e. one week after the first skin contact to the test substance indicate the possibility of skin sensitization. Based on the results, the test substance can be classified as R43 or Cat 1 according to EU or GHS standards.
Migrated from Short description of key information:
The test substance is sensitizing and can be classified as R43 or Cat 1 according to EU or GHS standards.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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