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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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The water solubility determination was performed according to column eluation method (OECD guideline 105). The water solubility of the 1-((2-Butyloctyloxymethyl)-2-(3,4-dihydro-isoquinolinium-2-yl)ethyl)sulfate amounts to 2.5 mg/L +/- 0.08 mg/L at T = 20.0°C +/- 0.1°C. Thus, determination of the hydrolysis as a function of pH of 1-((2-Butyloctyloxymethyl)-2-(3,4-dihydro-isoquinolinium-2-yl)ethyl)sulfate is scientifically unjustified and not required under REACH. According to Annex VII Sect., Col. 2, no further tests are required.

1-((2-Butyloctyloxymethyl)-2-(3,4-dihydro-isoquinolinium-2-yl)ethyl)sulfate was tested in a carbon dioxide evolution test according to OECD guideline 301B. The test was left running for 28 days. Aniline was chosen as positive control. Biodegradation of the positive control was 99.7% (28th day). The biodegradation of the test item is 26 % (28th day). In this test, the test substance is considered partly or moderately biodegradable, but the test substance is considered not readily biodegradable.

1-((2-Butyloctyloxymethyl)-2-(3,4-dihydro-isoquinolinium-2-yl)ethyl)sulfate was tested in a bioconcentration test to Zebrafish (Danio rerio) over an uptake period of 14 days followed by a depuration period of 16 days according to the US EPA Guideline, OPPTS 850.1730, the OECD-Guideline 305, 1996 and the MITI-Guideline to the Testing Methods for New Chemical. The bioconcentration factor for 1-((2-Butyloctyloxymethyl)-2-(3,4-dihydro-isoquinolinium-2-yl)ethyl)sulfate was 9.1 based on the mean of BCFss and BCFk. This value is based on total radioactivity in the whole fish on wet weight basis.

1-((2-Butyloctyloxymethyl)-2-(3,4-dihydro-isoquinolinium-2-yl)ethyl)sulfate was tested using High-Performance Liquid Chromatography (HPLC) according to OECD guidelines 121. The estimated log Koc was 3.9.