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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
2 (reliable with restrictions)

Data source

Reference Type:
Report date:

Materials and methods

Test guideline
no guideline followed
Principles of method if other than guideline:
Method denoted in paper:
hydroxytyrosol [2-(3,4-dihydroxyphenyl)-ethanol, C8H10O3, CAS RN: 10597-60-1, 1OH] were purchased from and TCI-Europe-NV, samples were carefully dried under vacuum and used without further purification.
Electrospray ionization/ion trap mass spectroscopy studies (ESI/IT MS; LCQ-DecaXP LC−MS system, ThermoFinnigan) were performed for the hydroxytyrosol, confirming its molecular weight according to what was expected.
From the thermoanalysis study of the samples by DSC (PerkinElmer Pyris 1) over the temperature ranges considered. no phase transitions were observed. Molar heat capacities at constant pressure were also experimentally determined by DSC, following the methodology “scanning method” previously described in the literature.

Literature: Callanan, J. E.; Sullivan, S. A. Development of standard operating procedures for differential scanning calorimeters. Rev. Sci. Instrum. 1986, 57, 2584−2592.

From Supporting information:
DSC was also used for controlling the thermal stability and measuring the heat capacities of samples studied, which were weighed (2-5mg) with a Mettler AT21 microbalance (± 1 µg) and hermetically sealed in aluminum pans. The corresponding thermograms were recorded with a heating rate of 0.17 K·s-1. The molar heat capacities at constant pressure, were obtained following the methodology (“scanning method”) previously described in the literature, using synthetic sapphire (α-aluminium oxide) as reference material.
Type of method:
differential scanning calorimetry

Test material

Chemical structure
Reference substance name:
EC Number:
Cas Number:
Molecular formula:
Specific details on test material used for the study:
Hydroxytyrosol [2-(3,4-dihydroxyphenyl)-ethanol, C8H10O3, CAS: 10597-60-1, 1OH] was purchased from TCI-Europe-NV.

Samples were carefully dried under vacuum and used without further purification.

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
>= 338.1 - <= 338.5 K

Applicant's summary and conclusion

The onset temperature of melting point for Hydroxytyrosol was determined to be 338.3 ± 0.2 K