1,2-Benzenediol, 4-(2-hydroxyethyl)-

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Method denoted in paper:
hydroxytyrosol [2-(3,4-dihydroxyphenyl)-ethanol, C8H10O3, CAS RN: 10597-60-1, 1OH] were purchased from and TCI-Europe-NV, samples were carefully dried under vacuum and used without further purification.
Electrospray ionization/ion trap mass spectroscopy studies (ESI/IT MS; LCQ-DecaXP LC−MS system, ThermoFinnigan) were performed for the hydroxytyrosol, confirming its molecular weight according to what was expected.
From the thermoanalysis study of the samples by DSC (PerkinElmer Pyris 1) over the temperature ranges considered. no phase transitions were observed. Molar heat capacities at constant pressure were also experimentally determined by DSC, following the methodology “scanning method” previously described in the literature.

Literature: Callanan, J. E.; Sullivan, S. A. Development of standard operating procedures for differential scanning calorimeters. Rev. Sci. Instrum. 1986, 57, 2584−2592.

From Supporting information:
DSC was also used for controlling the thermal stability and measuring the heat capacities of samples studied, which were weighed (2-5mg) with a Mettler AT21 microbalance (± 1 µg) and hermetically sealed in aluminum pans. The corresponding thermograms were recorded with a heating rate of 0.17 K·s-1. The molar heat capacities at constant pressure, were obtained following the methodology (“scanning method”) previously described in the literature, using synthetic sapphire (α-aluminium oxide) as reference material.

Type of method:

differential scanning calorimetry

Test material

Test material information

1

Reference substance name:

4-(2-hydroxyethyl)benzene-1,2-diol

EC Number:

600-704-3

Cas Number:

10597-60-1

Molecular formula:

C8H10O3

IUPAC Name:

4-(2-hydroxyethyl)benzene-1,2-diol

Specific details on test material used for the study:

Hydroxytyrosol [2-(3,4-dihydroxyphenyl)-ethanol, C8H10O3, CAS: 10597-60-1, 1OH] was purchased from TCI-Europe-NV.

Samples were carefully dried under vacuum and used without further purification.

Results and discussion

Melting / freezing point

Key result

Melting / freezing pt.:

>= 338.1 - <= 338.5 K

Applicant's summary and conclusion

Conclusions:

The onset temperature of melting point for Hydroxytyrosol was determined to be 338.3 ± 0.2 K