1,2-Benzenediol, 4-(2-hydroxyethyl)-

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March 19 - March 23 2020

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

yes

Remarks:

No Appendix containing a Test Item Certificate of Analysis Reason of change: The Sponsor does not supply a Test Item Certificate of Analysis since it is not available. Impact on the study: None

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: Knudsen cell

Test material

Test material information

1

Reference substance name:

4-(2-hydroxyethyl)benzene-1,2-diol

EC Number:

600-704-3

Cas Number:

10597-60-1

Molecular formula:

C8H10O3

IUPAC Name:

4-(2-hydroxyethyl)benzene-1,2-diol

Specific details on test material used for the study:

Packaging Aluminium sealed bag
Date of receipt March 05, 2020
Active ingredient content >99.0 % w/w
Batch number 17092019
Internal number 2001465-001
Production date September 17, 2019
Expiry date September 17, 2020
Storage condition
In the refrigerator at 4°C and in the dark in accordance with
the Test Substance Data Sheet (TSDS) supplied by the
Sponsor

Results and discussion

Vapour pressure

Key result

Temp.:

20 °C

Vapour pressure:

ca. 0.001 Pa

Remarks on result:

other: The test item vapour pressure can be estimated as follows: 7.08 x 10^ -4 Pa or 5.31 x 10^ -6 mmHg

Any other information on results incl. tables

Since the analysis was conducted under high vacuum conditions, the heat could be transferred only by radiation, this caused a consistent difference between the furnace temperature and the sample one and a considerable time for the system to reach equilibrium. The temperatures reported (registered by the thermocouple under the Knudsen cell) are hence different from the one set and the mass loss has been measured only in 80 minutes time interval within each isotherm, after the system had reached equilibrium. The last isotherms has been discarded because the test item evaporation was too fast and the pump was no more able to maintain the high vacuum. In addition, in the last two isotherms before the end of the test, the test item seems to be also completely evaporated and so no more information about TG/mg and Temp/°C is available to use for the Clausius – Clapeyron.

Applicant's summary and conclusion

Conclusions:

This study was performed to determine the vapour pressure of the test item supplied by the
Sponsor according to: OECD Guideline No. 104 and EC method A.4. The test item vapour pressure can be estimated as follows:
7.08 x 10^ -4 Pa or 5.31 x 10^ -6 mmHg at 20°C