Lithium iodide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2022

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2022

Report date:

2022

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Lithium iodide

EC Number:

233-822-5

EC Name:

Lithium iodide

Cas Number:

10377-51-2

Molecular formula:

ILi

IUPAC Name:

lithium iodide

Test material form:

solid

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Rationale for alternative/additional species to rat (if applicable)
- Source:
- Females (if applicable) nulliparous and non-pregnant: [yes/no]
- Rationale for use of males (if applicable)
- Age at study initiation:
- Weight at study initiation:
- Fasting period before study:
- Housing:
- Historical data:
- Diet (e.g. ad libitum):
- Water (e.g. ad libitum):
- Acclimation period:
- Microbiological status when known
- Method of randomisation in assigning animals to test and control groups

ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light):

IN-LIFE DATES: From: To:

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

physiological saline

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50 cut-off

Remarks:

500 mg/kg bw

Effect level:

> 300 - < 2 000 mg/kg bw

Based on:

test mat.

Mortality:

A dose of 2000 body weight was used as a starting dose for the 3 animals. The mortality of 3/3 animals at a limit dose of 2000 mg/kg body weight was observed. Administration of a dose of 2000 mg/kg body weight of Lithium Iodide Anhydrous to female Wistar rats caused the signs of systemic toxicity in 3/3 animals. In 2 animals (ID 2, 3), the symptoms occurred within 4 hours of the test item administration. Both animals died within 24 hours after test item administration. In one animal (ID 1), the clinical signs of toxicity were manifested with delay after 24 hours of administration. This animal died within 48 hours.

Clinical signs:

other:

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The LD50 of the test item Lithium Iodide Anhydrous is greater than 300 mg/kg body weight and lower than 2000 mg/kg body weight after single oral administration to female Wistar rats.
Based on Annex 2d Test Procedure with a Starting Dose of 2000 mg/kg body weight of OECD Guideline 423, the test item Lithium Iodide Anhydrous is classified in GHS Category 4. After single oral administration of Lithium Iodide Anhydrous to female Wistar rats, the LD50 cut-off value is 500 mg/kg body weight.