Registration Dossier
Registration Dossier
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EC number: 615-907-2 | CAS number: 73097-51-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- N1-methyl-4-(methylsulfonyl)benzene-1,2-diamine
- EC Number:
- 615-907-2
- Cas Number:
- 73097-51-5
- Molecular formula:
- C8H12N2O2S
- IUPAC Name:
- N1-methyl-4-(methylsulfonyl)benzene-1,2-diamine
- Test material form:
- other: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: HanRcc: WIST
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: PEG 300
- Doses:
- 300 or 2000 mg/kg body weight
- No. of animals per sex per dose:
- Three female rats per 300 mg /kg body weight
Six female rats per 2000 mg /kg body weight - Control animals:
- no
- Statistics:
- no statistics
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Three of the animals treated at 2000 mg/kg body weight were killed in extremis on the day of dosing or on day 2 of the study. Three animals treated at 2000 mg/kg and three animals treated at 300 mg/kg survived untit the end of the study period.
- Clinical signs:
- other: All animals treated at 2000 mg/kg expressed marked clinical signs of toxicity on the day of dosing and mild clinical signs were observed up to day 3 or 4. These included hunched posture, sedation, ruffled fur, ventral/lateral recumbency, poor coordination
- Gross pathology:
- Two of the animals treated at 2000 mg/kg body weight and killed in extremis were observed with hemorrhagic or hemorrhagic-watery fluid contents of duodenum and jejunum.
Otherwise, no macroscopic findings were recorded at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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