N,N’-di[3-(p-toluene sulfonyl)oxy]phenyl urea

Toxicity to microorganisms

Administrative data

Endpoint:

activated sludge respiration inhibition testing

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

July 27, 1995

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Water solubility:

ca. 0.364 µg/L

Conc. based on:

test mat.

Incubation duration:

ca. 23 d

Temp.:

20 °C

pH:

6.4 - 6.5

Details on results:

It was judged that the test results were valid as the maximum difference of concentrations was lower than 30% (see Table 3)

Table 3: Test results

Flow rate	pH	Water solubility (µg/L)	Average	Average of all values	Standard Deviation	Maximum difference (%)
0.4 mL/min	6.4	0.367	0.355	0.364	0.0197	22.0
	6.4	0.331
	6.4	0.379
	6.5	0.358
	6.4	0.340
0.2 mL/min	6.4	0.336	0.373		0.0437
	6.4	0.363
	6.5	0.415
	6.5	0.423
	6.5	0.330

Conclusions:

The water solubility of the test item is 0.364 µg/L at 20°C